Chemistry Learner

It's all about Chemistry

Home / Organic Chemistry / Agmatine


Agmatine is a chemical compound which functions as a neurotransmitter, helping in releasing pituitary hormones such as the Growth hormone and Luteinizing hormone. Due to this, they are frequently consumed as a useful dietary supplement by bodybuilders and athletes. It plays a pivotal role in polyamine biosynthesis. The German biochemist Albrecht Kossel first coined the term “Agmatine” in 1910 while studying herring sperm.

IUPAC Name for Agmatine

The IUPAC Name for this compound is N-(4-Aminobutyl)guanidine.

Other Names for Agmatine

Some of the other names for Agmatine include (4-Aminobutyl)guanidine and 1-Amino-4-guanidinobutane.


CAS reference number: 306-60-5

PubChem Substance ID: 199

ChemSpider Reference Number: 194

KEGG number: C00179

ChEBI: CHEBI: 17431

ChEMBL: CHEMBL58343, CHEMBL1256618

Beilstein Number: 1753874

Agmatine Picture
Picture 1 – Agmatine
Source –

Chemical Formula for Agmatine

The chemical formula for Agmatine is C5H14N4.

Production of Agmatine

Agmatine is produced by the decarboxylation of arginine.

Agmatine Properties

The physical and chemical properties of Agmatine are listed below:

Chemical Structure for Agmatine

The chemical structure of Agmatine is as follows:


Molecular Weight of Agmatine

The molecular weight or molar mass for this compound is 130.19 g/mol.


Agmatine appears as a solid structure under standard temperature and pressure.

Melting Point

The melting point for this compound is 102.2 °C.

Boiling Point

The boiling point for this chemical is 234.8 °C.


The density of Agmatine is 1.2g/cm3.

Vapor Pressure

The vapor pressure of this material is 0.052 mm Hg in a temperature of 25 °C.

Specific Heat of Vaporization

The specific heat of vaporization for Agmatine at STP is 0.3622 kilojoules/gram.

Critical Temperature

The critical temperature for this compound at STP is 733K.

Critical Pressure

The critical pressure for this compound at STP is 3.64 MPa.

Flash Point

The flash point for this substance is 95.8 °C.


Agmatine is highly soluble in water.

Agmatine Uses

Agmatine is chemically manufactured in the brain and stored in the synaptic vesicles which are then used in releasing important peptide hormones. It also helps in the production of Nitric Oxide while reducing the growth of enzymes like Nitric Oxide Synthase.

Agmatine helps in the secretion of important pituitary hormones such as growth hormones and Luteinizing hormones. Hence it is often consumed as an important health supplement by fitness enthusiasts, bodybuilders and athletes as well as by ageing people.

Consumption of this substance can also help to improve the mood as it has certain antidepressant and anti-anxiety properties.

Agmatine Sulfate

Agmatine sulfate is a popular form of health supplement which provides the same health benefits as Agmatine and is much more effective. It is found in white powder form.

The molecular formula of this compound is written as C5H14N4.H2SO4; C5H16N4O4S.

Agmatine Side Effects

Agmatine supplements should be consumed in dosages as recommended by physicians. Occasionally it can produce some gastrointestinal side effects such as vomiting, diarrhea and nausea. High consumption of this substance can reduce one’s overall tolerance of pain.

Agmatine is a chemical that serves as a powerful neurotransmitter. It can also be used to treat health problems in animals such as neurotrauma and ischemia.



Leave a Reply

Your email address will not be published.