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Fischer Indole Synthesis

Definition: What is Fischer Indole Synthesis?

The Fischer indole synthesis is an organic reaction used to convert a phenylhydrazine and an aldehyde or ketone to an indole using an acid catalyst, like Brønsted or Lewis acids. An application of this reaction is the synthesis of antimigraine drugs belonging to the triptan class [1-8].

Fischer Indole Synthesis

The history of this reaction goes back to 1883 when the reaction was first discovered by a German chemist Emil Fischer.

Examples of Fischer Indole Synthesis

The Fisher indole synthesis is used to synthesize 2-phenylindole and tetrahydrocarbazole [2,3,9].

Fischer Indole Synthesis Examples 2 Phenylindole Tetrahydrocarbazole

Mechanism of Fischer Indole Synthesis

Phenylhydrazone is formed from a condensation reaction of phenylhydrazine and an aldehyde or ketone. The phenylhydrazone converts into an indole in the presence of an acid catalyst [2-8,10].

Fischer Indole Synthesis Mechanism


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