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Grignard Reaction

Definition: What is Grignard Reaction?

Grignard reaction is a type of organometallic chemical reaction in which a Grignard reagent is added towater, alcohol, aldehyde, ketone, ester, and carbondioxide. The resulting product is a compound consisting of alkane or alcohol [1].

Mechanism of Grignard Reaction

Grignard reagent is very reactivedue the nucleophilic nature of the carbon atom present in the alkyl or aryl radical. It is used to perform nucleophilic addition reaction. The main role of this nucleophile is to attack the electrophilic carbon atom that is present in the carbonyl groupthat is present in aldehyde, ketone, and ester through single electron transfer mechanism [2]. This step is followed by protonation in presence of water and acid.

Grignard Reaction Mechanism with Water and Alcohol

Grignard Reaction for Water and Alcohol

Examples of Grignard Reaction with Water and Alcohol

Grignard Reaction Example with Water and Alcohol

Grignard Reaction Mechanism with Aldehyde and Ketone

Grignard Reaction Mechanism for Aldehyde Ketone

Grignard Reaction Mechanism with Ester

Grignard Reaction Mechanism for Ester

Examples of Grignard Reaction with Aldehyde, Ester, and Ketone

Grignard Reaction Example with Aldehyde Ketones and Ester

Grignard Reaction Mechanism with Carbondioxide

Grignard Reaction Mechanism for Carbondioxide

Examples of Grignard Reaction with Carbondioxide

Grignard Reaction Example with Carbondioxide

References:

  1. Definition of Grignard reaction – Organic-chemistry.org
  2. Mechanism of Grignard reaction – Study.com
  3. Mechanism and examples of Grignard reaction – Chemguide.co.uk
  4. Grignard reaction of alcohol – Socratic.org
  5. Grignard reaction with ester –Chemistryscore.com
  6. Grignard reaction with ester – Chem.libretexts.org
  7. Grignard reaction with ester – Chem.ucalgary.ca

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