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Michael Addition

Definition: What is Michael Addition?

Michael addition, also known as Michael reaction, is one of the most well-known reactions in organic synthesis. It is immensely useful for the formation of a carbon-carbon bond when a carbon nucleophile adds to an α, β-unsaturated carbonyl compound through a 1,4-addition mechanism. The product formed in the Michael addition reaction is called Michael adduct [1-4].

Michael Addition

The history of this reaction goes back to 1887 when Arthur Michael of Tufts University first synthesized a product through this procedure.

Examples of Michael Addition [5]

Michael Addition Examples

Michael Addition Thiol

Mechanism of Michael Addition [4-8]

Michael Addition Mechanism

Applications of Michael Addition

Michael addition is widely used to synthesize all kinds of natural products, drugs, and complex compounds with biological activities [9].

References

  1. Definition – Polymerdatabase.com
  2. Definition – Chemistryworld.com
  3. Definition – Chem.ucla.edu
  4. Definition and mechanism – Byjus.com
  5. Mechanism – Masterorganicchemistry.com
  6. Mechanism – Chem.ucalgary.ca
  7. Mechanism – Organic-chemistry.org
  8. Mechanism – Name-reaction.com
  9. Applications – Eurekaselect.com

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