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Michael Addition

Definition: What is Michael Addition?

Michael addition, also known as the Michael reaction, is one of the most well-known reactions in organic synthesis. It is a nucleophilic addition reaction. It is immensely useful for the formation of a carbon-carbon bond when a carbon nucleophile adds to an α, β-unsaturated carbonyl compound through a 1,4-addition mechanism. The product formed in the Michael addition reaction is called Michael adduct [1-4].

Michael Addition

The history of this reaction goes back to 1887 when Arthur Michael of Tufts University first synthesized a product through this procedure.

Examples of Michael Addition [5]

Michael Addition Examples

Michael Addition Thiol

Mechanism of Michael Addition [4-8]

Michael Addition Mechanism

Applications of Michael Addition

Michael addition is widely used to synthesize all kinds of natural products, drugs, and complex compounds with biological activities [9].


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One response to “Michael Addition”

  1. Jitu Gishu says:

    It good continue

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